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In the mid-19th century two intersecting railroads were built, the Wilmington and Manchester, and the Northeastern.and the burial ground adjacent to the prison became the Florence National Cemetery after the war and now has expanded.The city is located 80 miles (130 km) east from the state capital Columbia, 70 miles (110 km) west from Myrtle Beach, 120 miles (190 km) North of Charleston, and 110 miles (180 km) southeast of Charlotte, North Carolina.This has allowed Florence to remain competitive and bringing in and sustaining major manufacturers such as Honda, QVC Distribution Center and Otis Elevator.Mayors serve as a member of the city council, without term limits.



The growth of these providers has led to the transformation of the Florence skyline over the last 10 years, with development for demand with multi-story high-rises as well as community relation projects.After the war, Florence grew and prospered, using the railroad to supply its cotton, timber, and by the turn of the century, tobacco.During the 20th century the economy of Florence came to rely heavily on the healthcare industry, driven by two major hospitals and a number of pharmaceutical plants.With such a strong medical community several companies have their global, continental, or national headquarters in Florence, including General Electric Medical Systems manufacturing operations {MRI (anufacturing), TRICARE, a supplemental insurance company that serves the US Armed Forces and its civilian employees, and Assurant, a real property and personal insurance company.

The city also serves the pharmaceutical industry, with a Patheon pharmaceutical manufacturing facility and research and development center for Patheon API Services.

It is the county seat of Florence County and the primary city within the Florence metropolitan area.